Tuesday, October 22, 2013

Copper nanoparticle-catalyzed cross-coupling of alkyl halides with Grignard reagents

by Ju Hyun Kim and Young Keun Chung*

Graphical abstract: Copper nanoparticle-catalyzed cross-coupling of alkyl halides with Grignard reagents


A cross-coupling reaction between alkyl bromides and chlorides and various Grignard reagents was carried out in the presence of commercially available copper or copper oxide nanoparticles as a catalyst and an alkyne additive. The catalytic system shows high activity, a broad scope, and good functional group tolerance.

Chemical Communications
DOI: 10.1039/C3CC46419A

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