by Teerawut Bootwicha, Xiangqian Liu, Roman Pluta, Dr. Iuliana Atodiresei, Prof. Dr. Magnus Rueping*
Cinchona alkaloid catalysts in combination with
air- and moisture-stable N-trifluoromethylthiophthalimide as
electrophilic SCF3 source enabled the catalytic
enantioselective trifluoromethylsulfenylation. Thus, a series of α-SCF3 esters
that bear a quaternary carbon stereogenic center were obtained with excellent
yield and enantioselectivity. Moreover, the products can be readily converted
into valuable α-SCF3 β-hydroxyesters.
Angewandte Chemistry International
Edition
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