One step synthesis of benzoxazepine derivatives via a PPh3 catalyzed aza-MBH domino reaction between salicyl N-tosylimines and allenoates

by Hongxia Zhao, Xiangtai Menga and You Huang*

PPh₃-Catalyzed aza-MBH domino reaction of salicyl N-tosylimines with γ-CH₃ substituted allenoates is reported. Readily available imines and allenoates are converted to benzoxazepine derivatives in one step. Wherein, functionalization of C–H bonds of γ-substituted allenoate has been developed in this domino process.

Chemical Communications

DOI: 10.1039/C3CC46379F