Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide

by Jie Sheng, Shaoyu Li, Jie Wu

3-((Trifluoromethyl)thio)indoles can be accessed through a palladium(II)-catalyzed reaction of 2-alkynylaniline with trifluoromethanesulfanylamide in the presence of bismuth(III) chloride. The presence of bismuth(III) chloride is crucial for the success of this transformation, which would activate the trifluoromethanesulfanylamide during the process.

Chemical Communications
DOI: 10.1039/C3CC45958F