by Takashi Nishikata*, Yushi Noda, Ryo Fujimoto and
Tomomi Sakashita
α-Halocarbonyl
compounds undergo β-hydrogen elimination to give conjugated olefins in the
presence of a transition-metal catalyst. However, a copper/triamine catalyst
system can induce the alkylative Mizoroki–Heck reaction of styrenes with
tertiary-alkyl halides possessing a withdrawing group under very mild
conditions. This reaction provides an efficient synthetic methodology for
tertiary-alkylated styrenes.
Journal of the American Chemical Society
Publication Date (Web): October 21, 2013
No comments:
Post a Comment