Tuesday, October 8, 2013

Copper-Catalyzed ortho-Halogenation of Protected Anilines

by Juan Carlos Carretero, Beatriz Urones, Angel Manu Martinez, Nuria Rodriguez and and Ramon Gomez Arrayas*



A practical Cu-catalyzed direct ortho-halogenation of anilines under aerobic conditions has been developed. The reaction shows typically excellent mono-substitution selectivity, high ortho-regiocontrol and large functional group tolerance.

Chemical Communications

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