An Approach to Benzophosphole Oxides through Silver- or Manganese-Mediated Dehydrogenative Annulation Involving CC and CP Bond Formation

by Yuto Unoh, Koji Hirano, Tetsuya Satoh,* Masahiro Miura*

Benzophosphole construction was achieved through the Ag^I-mediated dehydrogenative annulation of phenylphosphine oxides with internal alkynes in a process involving CC and CP bond formation. A wide range of asymmetrical phenylacetylenes could be employed and the reactions proceeded with perfect regioselectivity. Moreover, the annulation could be conducted even at room temperature when a Mn^III promoter was used in place of Ag^I.

Angewandte Chemie International Edition

DOI:10.1002/anie.201307211