by Reto Frei, Davide Staedler, Aruna Raja, Raimo Franke, Florenz Sasse, Sandrine Gerber-Lemaire, Jérôme Waser*
Nature’s beauty: The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary investigations show that it inhibits the polymerization of tubulin, displaying significant cytotoxicity and antimigratory activity against both breast and lung cancer cell lines.
Angewandte Chemie International Edition
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