by Emma
Packard, David D. Pascoe, Jacques Maddaluno, Théo P. Gonçalves, David C.
Harrowven*
Changing
course: While organolithium and
Grignard reagents favor addition to C1 of A (R=Me), the corresponding
organoytterbium reagents add to C2 (R=tBu). Computational studies
provide insights into the nature of organoytterbium species and their
reactivity, and a total synthesis of (−)-mansonone B illustrates the utility of
the method in terpenoid synthesis. Tf=trifluoromethanesulfonyl.
Angewandte Chemie Internation Edition
Article first published online: 23 OCT 2013
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