by Christian Clavette, Jean-François Vincent
Rocan, Prof. Dr. André M. Beauchemin*
Behind the mask:
Nitrogen-substituted isocyanates are rare and their synthetic potential is
virtually untapped. Simple masked precursors can form amphoteric amino
isocyanate intermediates in situ, and allows the synthesis of complex hydrazine
derivatives upon addition with amines. This reactivity was used in a cascade
substitution/hydroamination sequence, and in the assembly of azadipeptide
analogues.
Angewandte Chemistry International Edition
DOI: 10.1002/anie.201306379
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