by Michal Szostak,* Brice Sautier, Malcolm Spain, Maike Behlendorf, David J. Procter*
Making a mark: Since the 1864 landmark discovery by Adolf von Baeyer, barbituric acids have played a prominent role in organic synthesis. Herein, the first chemoselective monoreduction of barbituric acids to the corresponding hemiaminals is described. The method delivers mono- and bicyclic hemiaminal products by a general single-electron-transfer polarity reversal mechanism.
Angewandte Chemie
International Edition
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