by Katsushi Kitahara, Jun Shimokawa and Tohru Fukuyama*
The asymmetric synthesis of spirotryprostatin A was achieved by employing an intramolecular Heck reaction to introduce the quaternary spiro center. The stereochemistry of the reaction was controlled by the tethering system, which was selectively introduced by taking advantage of the unique and as yet mysterious characteristics of the cyclo-(Pro-Pro) diketopiperazine moiety.
Chemical Science
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