by Justin
M. Pierson, Erica L. Ingalls, Richard D. Vo, Forrest E. Michael*
A
pincer for high selectivity: A mild
palladium-catalyzed hydroamination of protected amino-1,3-dienes has been
developed. This highly regioselective reaction employs a tridentate PNP pincer
ligand and leads to cyclic and homoallylic protected amines in high yields.
Substrates with a wide array of amine protecting groups and diene substitution
patterns were cyclized to form five- and six-membered heterocycles.
PG=protecting group.
Angewandte Chemie Internation Edition
Article first published online: 24 OCT 2013
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