by Weiqing Xie,* Guangde Jiang, Huan Liu, Jiadong Hu, Xixian Pan, Hui Zhang, Xiaolong Wan*, Yisheng Lai, Dawei Ma*
A shorter path: A highly enantioselective bromocyclization of tryptamine has been developed using an anionic chiral phase-transfer catalyst. This method provides a direct approach for preparing chiral 3-bromopyrroloindoline from tryptamine, which enables a four-step enantioselective synthesis of (−)-chimonanthine. PG=protecting group.
DOI: 10.1002/anie.201306774
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