by Renate Rohlmann, Constantin Gabriel Daniliuc, Olga Garcia Mancheno*
A concise enantioselective approach to medium-sized 7-ring O- and N-heterocycles has been developed. The synthetic strategy relies on an organocatalytic nitro-Michael/nitrile oxide cycloaddition tandem reaction, leading to the corresponding chiral benzoxe- and benzazepine derivatives containing an additional fused dihydroisoxazoline ring in good yields and excellent enantioselectivities (up to 97% ee).
Chemical Communications
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