Monday, October 28, 2013

Oxidant-Free Conversion of Primary Amines to Nitriles

by Kuei-Nin T. Tseng, Andrew M. Rizzi and Nathaniel K. Szymczak*


TOC Graphic

An amide-derived NNN-Ru(II) hydride complex catalyzes oxidant-free, acceptorless, and chemoselective dehydrogenation of primary and secondary amines to the corresponding nitriles and imines with liberation of dihydrogen. The catalyst system tolerates oxidizable functionality and is selective for the dehydrogenation of primary amines (−CH2NH2) in the presence of amines without α-CH hydrogens.

Journal of the American Chemical Society
Publication Date (Web): October 21, 2013


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