by Manuel Weber, Wolfgang Frey, René Peters*
Simple starting materials, high-value products: A dinuclear
ferrocene-based PdII complex transforms mixtures of racemic N-benzoyl
α-amino acids, nitroolefins, acetic anhydride, and manganese acetate into
biologically interesting quaternary aminosuccinimides. The products are
obtained as single diastereomers in enantioenriched form. Key steps of the
cascade mechanism are a 1,4-addition of in situ generated azlactones to
nitroolefins and a Nef-type reaction.
Angewandte Chemie International Edition
Article first published online: 21 OCT 2013
No comments:
Post a Comment